[2] The 2021–22 Dr Harty Cup adopted a change in format.

The new format saw six first-round games, with three winners moving forward to the quarter-finals while the other three winners, six losers and Gaelcholáiste Mhuire contesting five second-round ties to determine the other last-eight teams.

[3] St Flannan's College unsuccessfully defended its title in round 2 against Cashel Community School.

[4][5] St Joseph's Secondary School won the Harty Cup final on 5 February 2022 at TUS Gaelic Grounds, 1–17 to 1–14, in Limerick, against Ardscoil Rís, in what was St Joseph's first ever meeting in a final and their first ever Harty Cup title.

[6] St Joseph's Secondary School's Seán Withycombe was the top scorer.