The 2021–22 High Point Panthers men's basketball team represented High Point University in the 2021–22 NCAA Division I men's basketball season.

The Panthers, led by fourth-year head coach Tubby Smith through the first 26 games of the season and by interim head coach G. G. Smith for the remainder of the season, played their home games at the newly opened Qubein Center in High Point, North Carolina as members of the Big South Conference.

7 seed in the Big South tournament, they defeated Hampton in the first round before losing to Winthrop in the quarterfinals.

On February 16, 2022, Tubby Smith announced he was stepping down as head coach effective immediately.

They defeated USC Upstate in the first round of the Big South tournament[4] before losing to Winthrop in the quarterfinals.