The 2021–22 Holy Cross Crusaders men's basketball team represented the College of the Holy Cross in the 2021–22 NCAA Division I men's basketball season.

The Crusaders, led by third-year head coach Brett Nelson, played their home games at the Hart Center in Worcester, Massachusetts as members of the Patriot League.

In a season limited due to the ongoing COVID-19 pandemic, the Crusaders finished the 2020–21 season 5–11 in Patriot League play before suspending their season after positive COVID-19 tests within the program.

They did not participate in the Patriot League tournament.

Roster Last update: November 26, 2021 [1]