The 2021–22 season of the Hoofdklasse will be played in four leagues, two for Saturday and two for Sunday.
The 2021–22 Hoofdklasse will start on Saturday 28 August 2021.
After each period the best team which has not yet qualified earns a spot in the play-offs for the Derde Divisie as the period champion.
6 teams from the Saturday Hoofdklasse play against 2 teams from the Saturday Derde Divisie for 2 promotion spots.
They face the period champions of the Eerste Klasse.