The 2021–22 Horizon League men's basketball season began with practices in September 2021 and ended with the 2022 Horizon League men's basketball tournament in March 2022.

This was the 42nd season for Horizon League men's basketball.

Preseason Player of the Year: Antoine Davis, Detroit Mercy Below is a table of notable preseason watch lists.

The following table summarizes the multiple-team events (MTE) or early season tournaments in which teams from the Horizon League participated.

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