The Cougars were led by eighth-year head coach Kelvin Sampson.

The team played their home games at the Fertitta Center as members of the American Athletic Conference.

Houston went 3–1 in the tournament, reaching the Elite Eight before falling 44–50 to Villanova in the regional final.

Houston finished the season with a record of 32–6 and a ranking of #7 in the final Coaches Poll.

The team advanced to the Final Four for the first time since 1984, where they lost to eventual national champions Baylor.