2021–22 Howard Bison women's basketball team

The Bison, led by seventh-year head coach Ty Grace, played their home games at Burr Gymnasium in Washington, D.C. as members of the Mid-Eastern Athletic Conference (MEAC).

[3] They received an automatic bid to the NCAA tournament, where they were one of the sixteenth seeds in the Greensboro Region.

They defeated Incarnate Word in the First Four[4] before losing to eventual champions South Carolina in the first round.

[5] The Bison lost 79–21, with their total being a new record for lowest team score in any D-I women's tournament game.

The also trailed 44–4 at halftime, with their score also being the lowest in a half in tournament history.