The 2021–22 ISU Speed Skating World Cup was a series of speed skating competitions held from November 2021 to March 2022.

The series began on 12 November 2021 in Poland and ended on 13 March 2022 in Netherlands.

The World Cup is organised by the ISU who also runs world cups and championships in short track speed skating and figure skating.

World Cup titles were awarded to the top point earners in the 500m, 1000m, 1500m, Long Distances (combined 5000m/10000m), Mass Start, and Team Pursuit for men.

The competitions (except the finals in Heerenveen) were qualifying events for the 2022 Olympic Winter Games in Beijing, China.