The 2021–22 Illinois Fighting Illini women's basketball team represented the University of Illinois during the 2021–22 NCAA Division I women's basketball season.

The Fighting Illini, led by fifth-year head coach Nancy Fahey, played their home games at State Farm Center as members of the Big Ten Conference.

Due to the COVID-19 pandemic in the United States, the Illini played fewer non-conference games than in previous seasons; three games were originally postponed and later canceled due to the pandemic.

They lost in the second round of the Big Ten women's tournament to Northwestern.

Their first round win against Wisconsin was the first Big Ten tournament victory in coach Fahey's tenure at Illinois.