The 2021–22 Illinois State Redbirds women's basketball team represented Illinois State University during the 2021–22 NCAA Division I women's basketball season.

As the fourth seed in the Missouri Valley Tournament, they earned a bye into the Quarterfinals and defeated Loyola–Chicago, Southern Illinois, and Northern Iowa to win the championship.

They received an automatic bid to the NCAA tournament, where they were the fifteenth seed in the Greensboro Region.

As the third seed in the Missouri Valley Tournament, they earned a bye into the Quarterfinals where they lost to Loyola–Chicago.

They received an at-large bid to the WNIT, where they lost to Tulane in the First Round, defeated Samford in the Consolation Semifinal and lost to UT Martin in the Consolation Final.