The 2021–22 Indiana Hoosiers women's basketball team represented the Indiana University Bloomington during the 2021–22 NCAA Division I women's basketball season.

The Hoosiers were led by head coach Teri Moren in her eighth season, and played their home games at the Simon Skjodt Assembly Hall as a member of the Big Ten Conference.

The Hoosiers finished the 2020–21 season with a 21–5 record, including 16–2 in Big Ten play to finish in second place in the conference.

They received an at-large bid to the 2021 NCAA Division I women's basketball tournament, where they advanced to the Elite Eight.

[1] Roster Last update: January 27, 2022 * Coaches did not release a week 1 poll.