The Hawkeyes were led by head coach Lisa Bluder in her twenty-second season, and played their home games at Carver–Hawkeye Arena as a member of the Big Ten Conference.

[2] This 2021–22 team became the first in women’s basketball program history to win both the Big Ten regular season and tournament titles in the same year.

[2] On Selection Sunday, Iowa was announced as the number 2 seed for the Greensboro Region, the team's fourth consecutive appearance in the NCAA tournament.

Sophomore Caitlin Clark was named Big Ten Player of the Year and a unanimous first-team All-American.

They received an at-large bid to the 2021 NCAA Division I women's basketball tournament, where they advanced to the Sweet Sixteen.