The 2021-2022 Israeli Basketball National League was the 22nd season as second tier since its re-alignment in 2000 and the 68th season of second-tier basketball in Israel.
The following teams have changed division since the 2020–2021 season.
Promoted from Liga Artzit Relegated from Premier League[3] Promoted to Premier League[4] Relegated to Liga Artzit[6][7] if necessary
if necessary