The 2021–22 James Madison Dukes men's basketball team represented James Madison University in the 2021–22 NCAA Division I men's basketball season.

The Dukes, led by second-year head coach Mark Byington, played their home games at the Atlantic Union Bank Center in Harrisonburg, Virginia as members of the Colonial Athletic Association.

On November 6, 2021, the school announced that it would leave the CAA to join the Sun Belt Conference effective June 30, 2022.

Byington was named the CAA Coach of the Year while guard Matt Lewis was named the CAA Player of the Year.

[3] In the conference's preseason poll, the Dukes were picked to finish fourth, but were one of six schools to receive first place votes.