59 teams contested, beginning in August with the first of two preliminary rounds, and concluded on 17 April 2022 with the final played at De Kuip in Rotterdam.

[1] Ajax unsuccessfully defended its 2021 title[2] in PSV's successful pursuit of their 10th KNVB Cup, 2–1.

PSV contested the 2022 Johan Cruyff Shield against 2021–22 Eredivisie champions Ajax.

The draw was conducted by Oskar van Logtestijn, player of vv Hoogland.

Ajax, AZ, Feyenoord, PSV and Vitesse automatically advanced to the second round due to their participation in the European club competitions.