The 2021–22 season was Kalamata Football Club's 54th in existence and the club's first season in Super League Greece 2, the second level in Greek football, after the 2009–2010 season, when Kalamata was relegated to the amateur leagues .

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

Kalamata's pre-season began on the 2nd of August at Paliambela training ground.

From 9 to 22 August Kalamata was training at Portaria were the first friendly of the pre-season against Olympiakos Volou took place.