The Jayhawks, members of the Big 12 Conference, played their home games at Allen Fieldhouse in Lawrence, Kansas.

It was the 10th consecutive, 16th under Bill Self, and 24th time since the 1992–93 season KU was ranked 7th or higher in the preseason AP poll.

The Jayhawks defeated Texas on March 5 to clinch their 63rd regular season conference title, extending their NCAA record.

After defeating Providence in the NCAA tournament, Kansas passed Kentucky to be the winningest program in the nation.

[6] The Jayhawks defeated North Carolina in the National Championship game 72–69 after trailing 25–40 at halftime.

Seniors from the previous season, due to receiving an extra year of eligibility from the NCAA, had to declare to intention to enter the draft.

Roster Last update: February 5, 2022 Unlike the previous year, Kansas allowed full capacity crowds.

The Jayhawks had their first confirmed case of COVID-19 on February 1, 2022, when Ochai Agbaji tested positive for the virus.