The Wildcats were led by 10th-year head coach Bruce Weber and played their home games in Bramlage Coliseum in Manhattan, Kansas as members of the Big 12 Conference.

They lost to West Virginia in the first round of the Big 12 tournament.

[1] On March 21, the school named longtime Baylor assistant Jerome Tang the team's new head coach.

[2] In a season limited due to the ongoing COVID-19 pandemic, the Wildcats finished the 2020–21 season 9–20, 4–14 in Big 12 play to finish in ninth place.

They defeated TCU in the first round of the Big 12 tournament before losing to Baylor in the quarterfinals.