The Wildcats were led by eighth-year head coach Jeff Mittie.

They played their home games at Bramlage Coliseum in Manhattan, Kansas and were members of the Big 12 Conference.

On January 23, 2022 against Oklahoma, junior Ayoka Lee set an NCAA women's basketball record of 61 points in a single game, breaking the previous record of 60 points.

As the tenth seed in the Big 12 Tournament, they defeated Texas Tech in the First Round before losing to West Virginia in the Quarterfinals.

Roster Source:[1] 2021–22 NCAA Division I women's basketball rankings