The 2021–22 Kategoria e Parë was the 74th official season of the Albanian football second-tier since its establishment.
The winning and runner-up teams gained promotion to the 2022-23 Kategoria Superiore.
[2] Bylis and Erzeni were promoted to the 2022–23 Kategoria Superiore.
Butrinti, Maliqi, Pogradeci, Shkumbini and Vora were relegated to the 2022–23 Kategoria e Dytë.
Korabi qualified to the final play-off match.