[8] In between the unbeaten run, the Blasters moved to the top spot in league table for the first time in seven years during the middle of the season following their 2–0 victory over Odisha in the same month.
[19][20] On 8 April, the Blasters announced the signing of young center-back Ruivah Hormipam from I-League club Punjab FC on a three-year deal.
[25][26] On 6 June, the Blasters announced Ritwik Das, Rohit Kumar and Shaiborlang Kharpan have left the club as their contract ran out.
[27][28][29] On 12 June, the Blasters announced that Gary Hooper, Jordan Murray, Costa Nhamoinesu, Bakary Koné, Facundo Pereyra and Vicente Gómez, the six foreign players has left the club as their contract came to an end.
[62][63] On 31 August, the Blasters announced the departure of Subha Ghosh to SC East Bengal on a season long loan deal.
[66][67] On 31 August, the Blasters announced the departure of Naorem Mahesh Singh to East Bengal on a season long loan deal.
[76][77] On 11 September, the Blasters played their debut match in the Durand Cup against Indian Navy, which they won 0–1 after Adrián Luna netted a penalty in the 71st minute of the game.
[84][85] On 15 September, the Blasters played their second match in the Durand Cup against rivals Bengaluru FC, which they lost 2–0, after going down to 8-men after a series of red cards.
[86][87] On 16 September, the Blasters announced the signing of Croatian, Marko Lešković, as their last foreign player of the season on a one-year deal.
[92][93] The jersey was a homage to the Kerala football team that won the 1973 Santosh Trophy [94][95] On 21 September, the Blasters played Delhi FC in their last match in the group stages of the 2021 Durand Cup, which they lost 1–0, resulting in their elimination from the tournament.
[96][97] On 23 September, the Blasters announced their returning date to Kochi from Kolkata after their Durand Cup exit, and their plans to continue pre-season games and trainings ahead of the upcoming season.
[105][citation needed] On 12 October, the Blasters played their fifth pre-season friendly match against MA Football Academy, which they won 3–0.
[119][120] On 3 November, the Blasters announced their extension of association with BodyFirst as the team's official Nutrition Partner for the upcoming season.
[140] On 19 November, the Blasters played their first match of the 2021–22 Indian Super League season against ATK Mohun Bagan, which they lost 4–2.
[141][142] On 22 November, the Blasters announced that Rahul K. P. would exit the bio-bubble in Goa, after he was contracted with an injury in the match against ATK Mohun Bagan.
[152][153] On 11 December, the Blasters announced that the goalkeeper Albino Gomes has been ruled out indefinitely due to injury that he sustained during the match against Odisha.
[156][157] On 13 December, the Blasters gave a statement on the complaint they filed to AIFF regarding the poor refereeing measures in the past two fixtures.
[168][169] On 23 December, the Blasters announced the loan departure of Sreekuttan V. S. and Abdul Hakku to Gokulam Kerala FC for the 2021–22 I-League season.
[178][179] On 10 January, the Blasters gave a statement on the injury sustained by the captain Jessel Carneiro during the match against Hyderabad on the previous day.
[186][187] On 19 January, it was announced that the Blasters' match against ATK Mohun Bagan in the next day was postponed due to them being unable to field a team as a result of the COVID-19 outbreak in the camp.
[188][189] On 30 January, the Blasters played their second game of the season against Bengaluru in the Southern Derby, which they lost 0–1, thus giving an end their 10-match unbeaten streak.
[194][195] On 12 February, the Blasters gave a statement on the injury sustained by Ruivah Hormipam during the match against Jamshedpur, two days back.
[200][201] On 23 February, the Blasters forward Pereyra Díaz was charged with violent conduct by the All India Football Federation Disciplinary Committee for his actions after being substituted in the match against ATK Mohun Bagan four days back.
[206][207] On 2 March, the Blasters defender Harmanjot Khabra was charged with violent conduct and was fined ₹1.5 lakh by the All India Football Federation Disciplinary Committee for 'hitting an opponent' in the match against Hyderabad in February.
[258] Note: This is awarded monthly to the players of Kerala Blasters as chosen by the fans via voting in their social media platforms.
Note: This is awarded monthly to the players of Kerala Blasters as chosen by the fans via voting in their social media platforms.