The 2021–22 LBA season is the 100th season of the Lega Basket Serie A (LBA), the men's top-tier professional basketball division of the Italian basketball league system.

Virtus Roma withdrew in the past season.

Cantu ended on 15th place and therefore relegated to the Serie A2.

Source:[16] A total of 38 FIP officials set to work on the 2020–21 season in Lega Basket Serie A:[37] In the regular season, teams play against each other home-and-away in a round-robin format.

The playoffs started in May 2022 and finished in June 2022.