[1] The draw took place in Šibenik during the women's LEN European Junior Water Polo Championship.

The losers in the third round will be transferred in the Euro Cup quarter-finals.

[5] The draw for the 2021–22 LEN Champions League preliminary round took place in Ostia, Italy.

[6] The upcoming season is planned with the usual pre-pandemic round-robin format with 14 rounds contested on a home-and-away basis.

Marco Del Lungo, Francesco Di Fulvio, Luka Loncar, Gergő Zalánki, Aaron Younger, Alessandro Velotto, Nicholas Presciutti, Gonzalo Echenique, Aleksandar Ivović, Benjamin Thomas, Matteo Aicardi, Stefano Luongo, Tommaso Negri Head coach Sandro Sukno