The 2021–22 LSU Tigers women's basketball team represented Louisiana State University during the 2021–22 NCAA Division I women's basketball season.

The Lady Tigers, led by first-year head coach Kim Mulkey, played their home games at the Pete Maravich Assembly Center and competed as members of the Southeastern Conference (SEC).

The Tigers finished the season 9–13 (6–8 SEC) to finish in eighth in the conference.

Head coach Nikki Fargas resigned at the end of the season to become president of the Las Vegas Aces.

Baylor head coach Kim Mulkey was hired to replace her.