The Lady Cardinals, led by third-year head coach Aqua Franklin, played their home games at the Montagne Center in Beaumont, Texas as members of the Western Athletic Conference.

Lamar was one of four schools, all from Texas, that left the Southland Conference in July 2021 to join the WAC.

The seventh-seeded Lady Cardinals won their WAC tournament opening-round game against tenth seed New Mexico State 65–54.

Their season ended with a first-round tournament loss to sixth seed 2021–22 Sam Houston State Bearkats women's basketball team The Lady Cardinals finished the 2020–21 season with an overall record of 10–14 and 9–6 in conference play.

Their season ended losing to Central Arkansas in a quarterfinal game in the Southland Conference tournament.