2021–22 Liga Portugal 2

A total of 18 teams contest the league, including 13 sides from the 2020–21 season, 3 teams relegated from the 2020–21 Primeira Liga and 2 promoted from the 2020–21 Campeonato de Portugal.

Cova da Piedade failed to produce valid licensing documentation to compete in the 2021–22 season of the Liga Portugal 2, so they have been relegated by the Portuguese Football Professional League to the Liga 3.

As a result, Vilafranquense, that finished in 17th place in the 2020–21 Liga Portugal 2 were invited to play in the second tier for the 2021–22 season.

The table lists the positions of teams after each week of matches.

In order to preserve chronological evolvements, any postponed matches are not included to the round at which they were originally scheduled, but added to the full round they were played immediately afterwards.