The 2021–22 Liga Primera de Nicaragua season was to be divided into two tournaments, Apertura and Clausura.

Junior Managua finished last in the aggregate table and were relegated to the Segunda División.

The 9th place team in the aggregate table, Chinandega FC, faced the second-place team from the Segunda División, HyH Export de Sébaco, in a playoff for a spot in the Primera División.

HyH Export de Sébaco won 5–3 over two legs, meaning Chinandega FC relegated from the Primera División.

ART Jalapa were stripped the victory therefore allowed H&H Sebaco to overtake them on the table Managua FC progressed.