[1] The league fixtures were announced on 25 June 2021.

On 23 April, Paris Saint-Germain won a record-equalling tenth title with four matches to spare following a 1–1 draw against Lens.

[4] A total of twenty teams participated in the 2021–22 edition of the Ligue 1.

The 2021–22 season ended with a relegation play-off between the 18th-placed Ligue 1 team, Saint-Étienne, and the winner of the semi-final of the Ligue 2 play-off, Auxerre, on a two-legged confrontation.

Wissam Ben Yedder (Monaco)