2021–22 Louisville Cardinals men's basketball team

The team played its home games on Denny Crum Court at the KFC Yum!

Center in downtown Louisville, Kentucky as members of the Atlantic Coast Conference.

[2] On March 16, the school named former Louisville player Kenny Payne the team's new head coach.

[5][6] When all teams were able to participate in the opening rounds of the NCAA tournament, the Cardinals season ended.

[9] The school said that Mack was being suspended for failing to follow university guidelines regarding the matter.