The 2021–22 Loyola Greyhounds men's basketball team represented Loyola University Maryland in the 2021–22 NCAA Division I men's basketball season.
The Greyhounds, led by fourth-year head coach Tavaras Hardy, played their home games at Reitz Arena in Baltimore, Maryland as members of the Patriot League.
As the #9 seed in the Patriot League tournament, they were scheduled to face Holy Cross in the first round, but a positive COVID-19 test within the Holy Cross program forced the Crusaders to forfeit the game, moving Loyola into the quarterfinals.
[1] In the quarterfinals, the Greyhounds upset top-seeded Navy.
[3] Their Cinderella run in the Patriot League Tournament would end in the championship game, where they lost to #2 seeded Colgate.