The Ramblers, led by first-year head coach Drew Valentine, played their home games at the Joseph J. Gentile Arena in Chicago, Illinois as members of the Missouri Valley Conference.

As a result, they received the conference's automatic bid to the NCAA tournament as the No.

[2] As a result, they received the conference's automatic bid to the NCAA tournament as a No.

[8] On April 20, Valentine announced the hiring of assistant coaches Amorrow Morgan, Sean Dwyer, and Patrick Wallace.

Sources: Roster After losing several game to cancellations and postponements due to COVID-19, Loyola and San Francisco agreed to play a game on January 6, 2022, on the campus of Salt Lake Community College.