[1] The winner of the cup has earned a place in the 2022–23 UEFA Europa Conference League.
[2] The previous season's cup was abandoned due to the COVID-19 pandemic in Luxembourg.
[3] Seven preliminary round matches were played on 8 September 2021.
[5] Sixteen third round matches were played on 30 and 31 October 2021.
[6] Eight fourth round matches were played on 6 April 2022.