Shkëndija are the defending champions, having won their fourth title in 2020–21.
[7] Note: Flags indicate national team as has been defined under FIFA eligibility rules.
The first 22 matchdays will consist of a regular double round-robin schedule.
The league standings at this point will then be used to determine the games for the last 11 matchdays.
In order to preserve chronological evolvements, any postponed matches are not included to the round at which they were originally scheduled, but added to the full round they were played immediately afterwards.