The 2021-22 Malian Première Division was the 55th season of the highest level of professional football in Mali.
The championship was contested by 18 teams, starting in November 2021 and finishing in July 2022.
AS Bakaridjan, Djoliba AC, and USC Kita all mounted strong title challenges and remained towards the top of the table throughout the season, but Djoliba AC eventually accumulated an eight-point lead and won the title with two games left.
Djoliba AC also beat AS Real Bamako in the Malian Cup final to complete the league-cup double.
[2] They will be replaced by Binga FC and US Bougouni, who both won their respective Tournoi de Montée pools.