Ħamrun Spartans were the defending champions, having won their eighth title in the previous season.

On 9 April, the previous season was abandoned due to the COVID-19 pandemic in Malta.

[1] Following the decision of the Maltese Football Association Executive Committee, the teams that had finished in the relegation places in the previous Premier League season would be relegated to the Challenge League due to having played the prerequisite 75% of matches for the seasons result to stand.

In the first round, every team plays each opponent twice, once "home" and once "away" (in actuality, the designation of home and away is purely arbitrary as most of the clubs do not have their own grounds), for a total of 22 games.

Teams that finish in positions 1–6 compete in the "Top Six" and teams that finish in positions 7–12 play in the "Play-Out".