The 2021–22 season was Manchester City Women's Football Club's 34th season of competitive football and their ninth season in the FA Women's Super League, the highest level of English women's football.

Source: FA WSL As a member of the first tier, Manchester City entered the FA Cup in the fourth round proper.

As a result of failing to progress from the Champions League qualifying rounds, Manchester City entered the FA Women's League Cup at the group stage.

Knockout stage Manchester City entered the revised format of the Champions League in the second qualifying round.

Second qualifying round Starting appearances are listed first, followed by substitute appearances after the + symbol where applicable.