The season covered the period from 1 July 2021 to 30 June 2022.

The Stags announced they would play friendlies against Retford United,[1] Matlock Town,[1] Grimsby Town,[1] Alfreton Town,[2] Hull City,[2] Coventry City,[1] Basford United[1] and Nottingham Forest U23s[1] as part of the club's pre-season preparations.

Source: [citation needed] Mansfield Town's fixtures were announced on 24 June 2021.

[4] On 7 July, the scheduled fixtures with Newport County were reversed due to renovation works at Rodney Parade.

[8] Mansfield were drawn at home to Preston North End in the first round.