The 2021–22 Marshall Thundering Herd women's basketball team represented Marshall University during the 2021–22 NCAA Division I women's basketball season.

The Thundering Herd, led by fifth-year head coach Tony Kemper, played their home games at Cam Henderson Center in Huntington, West Virginia as members of the Conference USA.

They finished with a record of 15–13, 10–8 in C-USA play to finish in fifth place in the East Division.

They lost to Rice in the second round of the C-USA tournament.