[6] The league was scheduled to begin on 19 September 2021[7] but the date was pushed back to 15 November 2021 after multiple participating clubs demanded to postpone the league start due to the ongoing COVID-19 pandemic in Nepal.
[9] A total of 14 teams, all based in the Kathmandu Valley, contested the league with a relegation system.
All Nepal Football Association allowed every team a maximum of four foreign players, including one from a SAARC-affiliated country.
[22] For the first time, one of the departmental teams, APF Club, signed foreign players.
[23] The league was scheduled to be played centrally in two venues in two cities in the Kathmandu Valley.