The 2021–22 season was the 12th in the history of Melbourne City Football Club In addition to the domestic league, Melbourne City also competed in the FFA Cup and AFC Champions League.

[1] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

[29] Despite finishing the group stage undefeated with 3 wins and 3 draws; Melbourne City finished in second place due to goal difference, missing out on an automatic spot in the knockout stage of the tournament.

They also didn't advance as one of the best runner-ups, due to Jeonbuk Hyundai Motors, Urawa Red Diamonds, and Kitchee performing better than them in their respective groups.

The list is sorted by squad number when total clean sheets are equal.