In addition to the domestic league, Melbourne Victory also participated in the FFA Cup.
The season was documented in the Network Ten, Paramount+ and Amazon Prime Video series Dream Big.
Before their 2021–22 season, Melbourne Victory announced on 19 April 2021 that Tony Popovic would be managing the club for three years.
[1] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.
Win Draw Loss Cancelled or postponed Last updated: 19 February 2022 Source: Competitions The league fixtures were announced on 23 September 2021.