The 2021–22 Mercer Bears women's basketball team represented Mercer University during the 2021–22 NCAA Division I women's basketball season.

The Bears, led by twelfth-year head coach Susie Gardner, played their home games at the Hawkins Arena as members of the Southern Conference (SoCon).

They finished the season 23–6, 13–1 in the Southern Conference, winning the regular season and tournament championships, and representing SoCon in the 2022 NCAA Division I women's basketball tournament.

Roster [1]