The Wolverines, led by third-year head coach Juwan Howard, played their home games for the 55th consecutive year at the Crisler Center in Ann Arbor, Michigan.

1 seed in the Big Ten tournament, they defeated Maryland in the quarterfinals before losing to Ohio State in the semifinals.

1 seed in the East region, where they defeated Texas Southern and LSU to advance to their fourth straight Sweet Sixteen.

Due to the COVID-19 pandemic, the NCAA granted an extra year of eligibility for all winter sport athletes.

[1] Despite this, seniors Rico Ozuna-Harrison, C. J. Baird, Luke Wilson and Austin Davis announced they would not return to Michigan.

[3] On April 10, Chaundee Brown declared for the NBA draft with the intention of hiring an agent.

[6] On June 24, 2020, Michigan received its first class of 2021 commitment from four-star small forward Isaiah Barnes.

[7] On July 6, Michigan received its second commitment of the 2021 class, three-star forward Will Tschetter.

[8] On July 10, Michigan received its third commitment of the 2021 class, four-star shooting guard Kobe Bufkin.

Bufkin became the first in-state prospect to commit to Michigan under head coach Juwan Howard.

[9] On August 19, Michigan received its fourth commitment of the 2021 class, four-star point guard Frankie Collins.

[10] On October 30, Michigan received its fifth commitment of the 2021 class, five-star forward Caleb Houstan.

[11] On November 9, Michigan received its sixth commitment of the 2021 class, five-star power forward Moussa Diabaté.

[13] Sources: Sources: Juwan Howard (Michigan) Roster Last update: April 1, 2021 Michigan began the season on November 10 with an 88–76 victory over the Buffalo Bulls, winning their 19th consecutive season opener.

[16][17] On November 16, Michigan was upset by Seton Hall 65–67 in the Gavitt Tipoff Games.

[18][19] On November 20, Michigan defeated UNLV 74–61 in the Roman Main Event semifinals.

[20][21] On November 21 Michigan lost to Arizona 62–80 in the Roman Main Event championship game.

Michigan was led by Dickinson with a game-high 23 points, 14 rebounds, three assists, three steals and a block for his eighth career double-double, while Houstan added a career-high 17 points, five rebounds, two steals and an assist, Brooks posted his eighth consecutive game in double figures with 10 points, and added four rebounds, five assists, three steals and a block, and Frankie Collins came off the bench and added a career-high eight points, four rebounds, three assists and a steal.

[27][28] On December 7, Michigan defeated Nebraska 102–67 in its Big Ten Conference season opener.

Michigan played without reserves Collins, Faulds, Johns and Williams II due to undisclosed medical reasons, while Jackson didn't make the trip for personal reasons.

This marked Rutgers first victory over Michigan in their 15-game series that began on December 20, 1933.

[37][38] After having two games postponed due to COVID-19 complications within the Michigan program, they returned to action on January 14 and lost to (No.

Michigan rallied from a seven-point half-time deficit, and scored the final six points of the game to secure the victory.

Brooks set the Michigan program record for career games played with 147.

Three players were also suspended one game for their actions, Diabate and Williams for Michigan, and Jahcobi Neath for Wisconsin.

[73][74] On March 10, Michigan opened its 2022 Big Ten men's basketball tournament play with a 69–74 loss to Indiana in the second round.

Michigan was without starting point guard Jones due to concussion protocol.

Dickinson and Brooks outscored the entire Tennessee roster in the second half, 33–31.

Michigan was led by Dickinson with 15 points, 15 rebounds, three assists and two blocks, for his second consecutive double-double of the tournament, while Brooks added 14 points, five rebounds, two assists and a steal.

Hunter Dickinson was a second team All-Big Ten honoree by both the coaches and the media.