The Wolverines were led by head coach Kim Barnes Arico in her tenth year, and played their home games at the Crisler Center.

This season was highlighted by Michigan reaching their highest ranking ever in the AP Poll at No.

[2] Naz Hillmon also became the program's all-time leading rebounder, surpassing the previous record set by Trish Andrew in 1993.

The Wolverines advanced to the Sweet Sixteen for the first time in program history.

[7] On September 10, 2021, Kim Barnes Arico signed a contract extension through the 2025–26 season.