Toledo won their second straight MAC regular season title with a 17–3 conference record.

[1] Fourth seeded Akron defeated Kent State in the final of the MAC tournament.

[2] With the automatic bid, Akron was the only MAC schools to qualify for the NCAA tournament where they lost to UCLA in the first round.

[3][4] Toledo accepted a bid to the National Invitation Tournament where they lost to Dayton in the first round.

[9] (First place votes in parentheses) MAC tournament champions: Buffalo (8), Bowling Green (1), Kent State (1), Miami (1), Toledo (1) [10] [11] 2021–22 Mid-American Conference women's basketball season