The 2021–22 Mid-American Conference women's basketball season began with practices in October 2021, followed by the start of the 2021–22 NCAA Division I women's basketball season in November.

Toledo won the MAC regular season championship with a conference record of 19–1.

Second seeded Buffalo won the MAC tournament with a 79–75 win over Ball State.

[1] With the automatic bid, Buffalo was the only MAC school to qualify for the NCAA tournament where they lost to Tennessee in the first round.

[5] (First place votes in parentheses) MAC Tournament Champion: Buffalo (5), Ohio (3), BGSU (2), Ball State (1), EMU (1) [6] [7] 2021–22 Mid-American Conference men's basketball season