The season covers the period from 1 July 2021 to 30 June 2022.

Middlesbrough finished the 2020–21 season in 10th position in the EFL Championship.

[3] Middlesbrough announced they will play friendly matches against Bishop Auckland,[4] Saltash United,[4] Tavistock,[4] Plymouth Argyle,[4] York City[5] and Rotherham United[6] as part of their pre-season preparations.

Source: [citation needed] Middlesbrough's fixtures were revealed on 24 June 2021.

[9] In the quarter-final, Boro were handed a home tie against Premier League side Chelsea.