The 2021–22 Minnesota Golden Gophers women's ice hockey season was the team's 25th season of play for the program.

They represented the University of Minnesota in WCHA women's ice hockey during the 2021–22 NCAA Division I women's ice hockey season.

They Golden Gophers won the WCHA regular-season title, but lost to Ohio State 3–2 in the conference tournament finals on home ice.

[4] After the conference tournament, the Gophers were selected as an at-large bid for the 2022 NCAA tournament, gaining the second seed overall, behind Ohio State.

They lost to the University of Minnesota–Duluth Bulldogs 2–1 at Ridder Arena in the NCAA Tournament Quarterfinals.