The team played its home games at Mizzou Arena in Columbia, Missouri as a tenth-year members of the Southeastern Conference.

On March 11, 2022, the school fired head coach Cuonzo Martin.

[2] In a season limited due to the ongoing COVID-19 pandemic the Tigers finish the 2020–21 season 16– 10, 8–8 in SEC play to finish in seventh place.

They defeated Georgia in the second round of the SEC tournament before losing to Arkansas.

Seniors listed below have the option to use their additional year of eligibility.