The 2021–22 Missouri Valley Conference men's basketball season began with practices in October 2021, followed by the start of the 2021–22 NCAA Division I men's basketball season in November.

With a win over Loyola Chicago on February 26, 2022, Northern Iowa clinched the regular season championship.

[3] The preseason awards and coaches' poll was released by the league office on October 20, 2021.

[4] Source[5] This table summarizes the head-to-head results between teams in conference play.

The MVC announced its all-conference teams and major playing honors on March 1, 2022,[23] and its Coach of the Year award two days later.